Rescue of impaired hippocampal consolidation in the APP/PS1 mouse model of Alzheimer’s disease after increasing cerebral blood flow
Laura E Berkowitz, Ralitsa Todorova, Ryan E Harvey, Jean‐Luc Shimizu, Xuelai Dong, Azahara Oliva, Antonio Fernandez‐Ruiz, Nozomi Nishimura, Chris B Schaffer · 2025
Read Rescue of impaired hippocampal consolidation in the APP/PS1 mouse model of Alzheimer’s disease after increasing cerebral blood flow by Laura E Berkowitz, Ralitsa Todorova, Ryan E Harvey, Jean‐Luc Shimizu, Xuelai Dong, Azahara Oliva, Antonio Fernandez‐Ruiz, Nozomi Nishimura, Chris B Schaffer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710124.txt.
Description
Laura Berkowitz and co-authors test whether raising brain blood flow rescues memory in mice, in a 2025 study. The mice carry gene changes that mimic Alzheimer disease in people. Such mice show weak spatial memory and faulty circuits in the hippocampus, a memory hub. Brief brain bursts there during sleep help lock in new memories, and those bursts shrink in the model mice.
Earlier work found that a treatment lifting blood flow also restored memory. Here the team recorded circuit activity in the memory hub during sleep, before and after field exploration. They sorted cell types and picked out firing groups that reactivate together. The study checks whether circuit patterns return to normal as flow rises.
Catalog record
| CREATOR | Laura E Berkowitz, Ralitsa Todorova, Ryan E Harvey, Jean‐Luc Shimizu, Xuelai Dong, Azahara Oliva, Antonio Fernandez‐Ruiz, Nozomi Nishimura, Chris B Schaffer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |