Targeting cannabinoid type 2 receptors alters human tau levels in ex vivo brain slice cultures
Valerie L Joers, Ila Bagheri, Jazmyn Coronado, Cecilia Hillard, Malu Gámez Tansey · 2025
Read Targeting cannabinoid type 2 receptors alters human tau levels in ex vivo brain slice cultures by Valerie L Joers, Ila Bagheri, Jazmyn Coronado, Cecilia Hillard, Malu Gámez Tansey (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710119.txt.
Description
Valerie Joers and co-authors test whether a cannabis-linked receptor can move tau levels in brain tissue. Their 2025 study uses mouse brain slice cultures carrying human tau genes. Tau tangles track closely with Alzheimer's symptoms, and immune cells in the brain may steer them.
The receptor, CB2, sits mostly on microglia and rises when they activate. Slices lacking the receptor showed no change in soluble tau. A drug that blocks the receptor the other way cut a phosphorylated tau form in the soluble part. The effect depended on which tau variant the slices carried. The authors read CB2 as a dial on immune handling of tau.
Catalog record
| CREATOR | Valerie L Joers, Ila Bagheri, Jazmyn Coronado, Cecilia Hillard, Malu Gámez Tansey |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |