Tau pathology increases α‐synuclein spreading from the periphery to the CNS
Carlos M Soto‐Faguás, Anna Bowman, Randall Woltjer, Vivek K Unni · 2025
Read Tau pathology increases α‐synuclein spreading from the periphery to the CNS by Carlos M Soto‐Faguás, Anna Bowman, Randall Woltjer, Vivek K Unni (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710115.txt.
Description
Carlos Soto-Faguás, Anna Bowman, Randall Woltjer, and Vivek Unni asked how two brain diseases feed each other in a 2025 study. Lewy body dementia mixes clumps of a protein called alpha synuclein with the plaques and tangles of Alzheimer's disease. How those proteins push each other along was not clear, and few animal models grow both at once.
Their new mouse line builds the synuclein clumps ten times faster than past models after a seed shot. They bred it with a tau model and shot seeds into a leg muscle. The tau mice showed more synuclein spread up the cord and into the brain. The work gives the field a model where both ills grow side by side.
Catalog record
| CREATOR | Carlos M Soto‐Faguás, Anna Bowman, Randall Woltjer, Vivek K Unni |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |