APOE4 to APOE2 ‘Switching’ in Astrocytes Alters the Cerebral Transcriptome and Decreases AD Neuropathology at Different Points on the AD Pathophysiological Timeline
Lesley R Golden, Isaiah O Stephens, Dahlia Siano, Steven M MacLean, Kumar Pandya, Scott Gordon, Josh M. Morganti, Lance A Johnson · 2025
Read APOE4 to APOE2 ‘Switching’ in Astrocytes Alters the Cerebral Transcriptome and Decreases AD Neuropathology at Different Points on the AD Pathophysiological Timeline by Lesley R Golden, Isaiah O Stephens, Dahlia Siano, Steven M MacLean, Kumar Pandya, Scott Gordon, Josh M. Morganti, Lance A Johnson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710112.txt.
Description
Lesley Golden and seven co-authors test a gene switch in the brain's astrocytes as a path to Alzheimer's care in a 2025 mouse study. One form of the APOE gene, E4, lifts the risk of the disease by a lot. Its kin form, E2, guards against it by a like scale.
A new mouse line lets the team flip the gene in astrocytes from E4 to E2, at a time of their choice. The flip is in one cell type alone. Brain gene reads and disease marks were then read at more than one point on the disease's path, to see how much the switch can heal.
Catalog record
| CREATOR | Lesley R Golden, Isaiah O Stephens, Dahlia Siano, Steven M MacLean, Kumar Pandya, Scott Gordon, Josh M. Morganti, Lance A Johnson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |