Effects of lifestyle factors on Alzheimer’s disease symptoms in adults with Down syndrome
Emily K Schworer, Matthew D Zammit, Benjamin L Handen, Ozioma C Okonkwo, Christy L. Hom, Beau Ances, Bradley T. Christian, Sigan L Hartley · 2025
Read Effects of lifestyle factors on Alzheimer’s disease symptoms in adults with Down syndrome by Emily K Schworer, Matthew D Zammit, Benjamin L Handen, Ozioma C Okonkwo, Christy L. Hom, Beau Ances, Bradley T. Christian, Sigan L Hartley (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710111.txt.
Description
Adults with Down syndrome face a very high lifetime risk of Alzheimer's disease, yet symptoms start at widely different ages. Emily Schworer and co-authors look for lifestyle factors that might delay symptoms. Sixty-three adults took part, most of them cognitively stable. Brain scans measured amyloid plaques, and each person received a chronicity score for plaque buildup. Memory tests and caregiver screens tracked symptoms. Caregivers also rated time in cognitive, social, and work activities. Wrist devices counted daily steps for a week.
The team combined the activity reports into one lifestyle score. They then tested whether lifestyle softened the link between plaques and symptoms. The design targets resilience: habits that might protect thinking even as plaques grow.
Catalog record
| CREATOR | Emily K Schworer, Matthew D Zammit, Benjamin L Handen, Ozioma C Okonkwo, Christy L. Hom, Beau Ances, Bradley T. Christian, Sigan L Hartley |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |