Higher amyloid burden is associated with faster reduction in cerebral blood flow: a longitudinal study
Tianrui Zhao, Jianing Tang, Jamie Terner, Elizabeth B Joe, Meredith N Braskie, Helena C Chui, Vasilis Marmarelis, Lirong Yan · 2025
Read Higher amyloid burden is associated with faster reduction in cerebral blood flow: a longitudinal study by Tianrui Zhao, Jianing Tang, Jamie Terner, Elizabeth B Joe, Meredith N Braskie, Helena C Chui, Vasilis Marmarelis, Lirong Yan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710094.txt.
Description
Zhao and co-authors studied how amyloid build-up in the brain relates to blood flow there, in a paper published in 2025. Amyloid is a hallmark of Alzheimer's disease and tracks with failing memory. Blood flow to the brain also falls in this disease, and vessel trouble adds to the harm. Whether amyloid speeds that fall was unclear. The team followed 168 older adults, measuring amyloid and blood flow more than once.
People with higher amyloid lost blood flow faster over time. The link held in both one-time snapshots and the follow-up data. Flow fell fastest in brain areas tied to the disease's early spread. The results tie the two processes together rather than treating them as separate tracks. They suggest that amyloid burden may warn of coming vessel decline. That link could matter for choosing when and how to intervene.
Catalog record
| CREATOR | Tianrui Zhao, Jianing Tang, Jamie Terner, Elizabeth B Joe, Meredith N Braskie, Helena C Chui, Vasilis Marmarelis, Lirong Yan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |