Differential Effects of Anticholinergic Medications in Patient hiPSC‐Derived Neurons
Tiara A. Schwarze‐Taufiq, Inez Pranoto, Katherine Hui, Jordan Ogg, Ruowei Zhu, Paul K. Crane, Shelly L Gray, Jessica E. Young · 2025
Read Differential Effects of Anticholinergic Medications in Patient hiPSC‐Derived Neurons by Tiara A. Schwarze‐Taufiq, Inez Pranoto, Katherine Hui, Jordan Ogg, Ruowei Zhu, Paul K. Crane, Shelly L Gray, Jessica E. Young (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710062.txt.
Description
Tiara Schwarze-Taufiq and seven colleagues test common drugs in lab-grown human neurons, published in 2025, to see if some may raise dementia risk. The drugs block a brain chemical messenger and are called anticholinergics. Older adults use them often, for mood, allergies, bladder problems, and stomach cramps. Population studies hint that risk differs by drug class, but those studies can mislead.
The team grew neurons from stem cells taken from study volunteers. They exposed the cells to eight drugs from four classes, at two doses and two time lengths. A standard messenger chemical served as the control. Effects differed sharply by drug. Several drugs harmed cells at higher doses, and some raised the share of a harmful amyloid form. One bladder drug did so most clearly. The authors say cell models can help sort real drug effects from study bias.
Catalog record
| CREATOR | Tiara A. Schwarze‐Taufiq, Inez Pranoto, Katherine Hui, Jordan Ogg, Ruowei Zhu, Paul K. Crane, Shelly L Gray, Jessica E. Young |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |