Cross‐Ancestry Meta‐Analysis of APOE‐ε4 Stratified GWAS of Longitudinal Cognitive Decline in Older Adults
Alex G. Contreras, Skylar Walters, Jaclyn M. Eissman, Derek B. Archer, Alexandra N. Regelson, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse Mez, William S. Bush, Brian W. Kunkle, Adam C. Naj, Katherine A. Gifford, Murat Bilgel, Amanda · 2025
Read Cross‐Ancestry Meta‐Analysis of APOE‐ε4 Stratified GWAS of Longitudinal Cognitive Decline in Older Adults by Alex G. Contreras, Skylar Walters, Jaclyn M. Eissman, Derek B. Archer, Alexandra N. Regelson, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse Mez, William S. Bush, Brian W. Kunkle, Adam C. Naj, Katherine A. Gifford, Murat Bilgel, Amanda (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710061.txt.
Description
Alex Contreras and a large team of co-authors search for genes that shape how the APOE gene affects memory loss, in a research paper from 2025. One form of APOE raises risk for Alzheimer disease, but the risk differs by ancestry. The team asks what other genes modify that effect over time.
The work pools genome scans across ancestry groups, split by APOE type. It tracks change in thinking scores in older adults over years. By testing for gene links within each group and for joint effects, the study hunts for modifiers. The findings may help explain why the same gene form acts in unlike ways in unlike groups.
Catalog record
| CREATOR | Alex G. Contreras, Skylar Walters, Jaclyn M. Eissman, Derek B. Archer, Alexandra N. Regelson, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi, Phoebe Scollard, Emily H. Trittschuh, Jesse Mez, William S. Bush, Brian W. Kunkle, Adam C. Naj, Katherine A. Gifford, Murat Bilgel, Amanda |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |