IGFBP‐5 Potentially Mediates the Association of Brain Insulin Signaling with Late‐Life Cognitive Decline
Han Tong, Ana W Capuano, David A Bennett, Rexford S Ahima, Steven E Arnold, Zoe Arvanitakis · 2025
Read IGFBP‐5 Potentially Mediates the Association of Brain Insulin Signaling with Late‐Life Cognitive Decline by Han Tong, Ana W Capuano, David A Bennett, Rexford S Ahima, Steven E Arnold, Zoe Arvanitakis (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710012.txt.
Description
Han Tong and co-authors probe how brain insulin signaling may drive late-life thinking decline in a 2025 study. Faulty insulin signaling in the brain has been tied to Alzheimer's disease and faster decline, but the chain between them is unclear.
The team studied 118 older adults who had yearly thinking tests in life and brain study after death, half with diabetes. They measured insulin signals and five related proteins in the front of the brain. One binding protein stood out as a possible middle step in the link. Another protein also tied to decline in the opposite direction. The authors frame both as leads for deeper work.
Catalog record
| CREATOR | Han Tong, Ana W Capuano, David A Bennett, Rexford S Ahima, Steven E Arnold, Zoe Arvanitakis |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |