Mapping the neuroimmune landscape of Alzheimer’s disease in African Americans
Nkechime E. Ifediora, Nivedita Nimmagadda, Emily Lee, Peter D. Canoll, Julie A. Schneider, David A. Bennett, Vilas Menon, Lisa L. Barnes, Marta Olah · 2025
Read Mapping the neuroimmune landscape of Alzheimer’s disease in African Americans by Nkechime E. Ifediora, Nivedita Nimmagadda, Emily Lee, Peter D. Canoll, Julie A. Schneider, David A. Bennett, Vilas Menon, Lisa L. Barnes, Marta Olah (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710003.txt.
Description
Nine researchers map immune cells in the brains of older African Americans with Alzheimer's disease, in a 2025 study. African Americans bear a heavier Alzheimer's burden, yet most brain immune research has centered on white donors. The team focused on microglia, the brain's resident immune cells, which are a favored target for future drugs.
They isolated live microglia from two brain regions of ten donors in a minority aging study. Single-cell profiling sorted the cells into nine types: two resting types and seven active, specialized types. The same types appeared as in white donors, but their proportions differed. The team added gene-access and protein profiles and compared the subsets with tissue signs of aging and disease. The distinct mix may shape how Alzheimer's unfolds in this group, and why treatments could work differently.
Catalog record
| CREATOR | Nkechime E. Ifediora, Nivedita Nimmagadda, Emily Lee, Peter D. Canoll, Julie A. Schneider, David A. Bennett, Vilas Menon, Lisa L. Barnes, Marta Olah |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |