Phenotypic characterization of a novel hAb‐KIloxP;hAPOE4;Trem2R47H_NSS mouse model
Angela Gomez‐Arboledas, Enikö Kramár, Shimako Kawauchi, Celia Da Cunha, Yueh Hao Lu, Giedre Milinkeviciute, Jonathan Neumann, Marcelo A Wood, Andrea J Tenner, Frank M LaFerla, Grant R MacGregor, Kim N. Green · 2025
Read Phenotypic characterization of a novel hAb‐KIloxP;hAPOE4;Trem2R47H_NSS mouse model by Angela Gomez‐Arboledas, Enikö Kramár, Shimako Kawauchi, Celia Da Cunha, Yueh Hao Lu, Giedre Milinkeviciute, Jonathan Neumann, Marcelo A Wood, Andrea J Tenner, Frank M LaFerla, Grant R MacGregor, Kim N. Green (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709884.txt.
Description
Angela Gomez-Arboledas and co-authors present a 2025 conference abstract on a new triple-gene mouse model of late-onset Alzheimer's disease. The mice combine human amyloid production with two strong risk variants, APOE4 and a TREM2 change. The team bred four groups and aged them to set points up to 24 months.
Mice with human amyloid alone showed a clear deficit in a measure of synaptic strengthening at every age. Adding APOE4, with or without the TREM2 variant, fully prevented that deficit. At 24 months, the combined groups also carried less soluble amyloid in cortex than amyloid-only mice. The model will help test how risk genes interact.
Catalog record
| CREATOR | Angela Gomez‐Arboledas, Enikö Kramár, Shimako Kawauchi, Celia Da Cunha, Yueh Hao Lu, Giedre Milinkeviciute, Jonathan Neumann, Marcelo A Wood, Andrea J Tenner, Frank M LaFerla, Grant R MacGregor, Kim N. Green |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |