Elevated amyloid‐ß and tau burden is associated with accelerated cognitive decline on a digital clock drawing test in preclinical AD
Jessie Fanglu Fu, Talia L Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J Jutten, Brian Healy, Grace A Del Carmen Montenegro, Emma G Thibault, Dana Penney, Randall Davis, Reisa A Sperling, Keith A Johnson, Julie C Price, Dorene M Rentz · 2025
Read Elevated amyloid‐ß and tau burden is associated with accelerated cognitive decline on a digital clock drawing test in preclinical AD by Jessie Fanglu Fu, Talia L Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J Jutten, Brian Healy, Grace A Del Carmen Montenegro, Emma G Thibault, Dana Penney, Randall Davis, Reisa A Sperling, Keith A Johnson, Julie C Price, Dorene M Rentz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709782.txt.
Description
Jessie Fanglu Fu and a large team of co-authors link brain protein buildup to decline on a digital clock drawing test, in a 2025 study. The test takes two minutes and records not just the drawn clock but pause and speed traces. Two hundred four adults with normal thinking took the test over time and had scans for two Alzheimer's-linked proteins.
High levels of either protein at the start tracked with faster decline on the test. The link sat most in one subscore, for information processing speed. Pause traits drove that link. When both proteins entered one model, only the second protein kept a clear tie. The authors see the cheap digital test as a fine early warning tool.
Catalog record
| CREATOR | Jessie Fanglu Fu, Talia L Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J Jutten, Brian Healy, Grace A Del Carmen Montenegro, Emma G Thibault, Dana Penney, Randall Davis, Reisa A Sperling, Keith A Johnson, Julie C Price, Dorene M Rentz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |