Comprehensive Multi‐Neuron Imaging During Aging and Degeneration in C. elegans
Dilip Yadav, Gregory Wirak, Christopher Connor, Chritopher Gabel · 2025
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Description
Dilip Yadav and co-authors use a tiny worm to watch many nerve cells at once as the animal ages and as disease-like damage sets in. The most common form of dementia in old age is still poorly understood at the level of single cells. No one fully knows how broken cell activity leads to lost thinking, or how that differs from normal aging.
With glowing markers and a scope, the team can record activity across most of the worm's nervous system, cell by cell. They track how the system's patterns and links break down with age and in a model of the disease. The worm is simple, yet its nerve cells share key traits with ours. The work may reveal early signs of decline.
Catalog record
| CREATOR | Dilip Yadav, Gregory Wirak, Christopher Connor, Chritopher Gabel |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |