Microglial Activation Alters Chromatin Accessibility of AD‐Associated Transcription Factors
Zena K Chatila, Jason Mares, Badri N Vardarajan, Wassim Elyaman, Vilas Menon, Elizabeth M Bradshaw · 2025
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Description
Brain immune cell waking and gene access shifts in Alzheimer disease are studied by Zena K. Chatila and co-authors in work dated 2025. Microglia, the brain's own immune cells, can be re-set by a first hit so later hits land in a new way. That re-set is called innate immune memory. The team grew a microglia-like cell model and hit it with a range of wakes, then let it rest a week.
Three wakes left last gene-access marks: two germ part types and one virus. Marks sat at spots for Alzheimer-linked gene switches. The marks also matched gene maps from real Alzheimer brains. Such prints may drive long cell faults.
Catalog record
| CREATOR | Zena K Chatila, Jason Mares, Badri N Vardarajan, Wassim Elyaman, Vilas Menon, Elizabeth M Bradshaw |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |