Unveiling the Pathogenic Influence of TDP‐43 on Tau‐Mediated Neurotoxicity in an Alzheimer’s Disease Mouse Model
Laura Garcia Toscano, Joshua C Hincks, Pamela J McMillan, Misa Baum, Sarah M Waldherr, Brian C Kraemer, Nicole F Liachko · 2025
Read Unveiling the Pathogenic Influence of TDP‐43 on Tau‐Mediated Neurotoxicity in an Alzheimer’s Disease Mouse Model by Laura Garcia Toscano, Joshua C Hincks, Pamela J McMillan, Misa Baum, Sarah M Waldherr, Brian C Kraemer, Nicole F Liachko (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709688.txt.
Description
Laura Garcia Toscano and co-authors study how a protein called TDP-43 may worsen the harm done by tau, a second protein, in Alzheimer's disease. Many patients with the disease build up TDP-43 in the brain as well as tau tangles, and those patients tend to worsen fast.
The team made a mouse that carries human tau and was given a virus that makes human TDP-43 in one side of a memory center of the brain. A harmless virus served as control. They then tracked the mice over weeks. The model lets them test whether TDP-43 sparks or speeds the toxic work of tau.
Catalog record
| CREATOR | Laura Garcia Toscano, Joshua C Hincks, Pamela J McMillan, Misa Baum, Sarah M Waldherr, Brian C Kraemer, Nicole F Liachko |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |