Extracellular Vesicles from Human iPSC‐derived NSCs Protect Human Neurons Against Aβ‐42 Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation
Shama Rao, Leelavathi N Madhu, Roshni S Babu, Advaidhaa Nagarajan, Esha Narvekar, Raghavendra Upadhya, Ashok K Shetty · 2025
Read Extracellular Vesicles from Human iPSC‐derived NSCs Protect Human Neurons Against Aβ‐42 Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation by Shama Rao, Leelavathi N Madhu, Roshni S Babu, Advaidhaa Nagarajan, Esha Narvekar, Raghavendra Upadhya, Ashok K Shetty (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709678.txt.
Description
Shama Rao and co-authors test whether tiny packages released by stem cells can protect neurons from Alzheimer's-related harm in a 2025 study. Amyloid-beta, a protein that builds up in the disease, drives cell stress, inflammation, and neuron death. Neural stem cells grown from reprogrammed human cells release vesicles loaded with proteins and small RNAs.
The team collected those vesicles and added them to mature human neurons exposed to a toxic form of amyloid. Treated neurons survived better on standard viability tests. Measures of cell stress fell, and genes tied to cell death, energy production, and cleanup shifted in protective directions. Tau protein changes, another mark of the disease, were also tracked. The results support vesicles as a candidate shield for neurons.
Catalog record
| CREATOR | Shama Rao, Leelavathi N Madhu, Roshni S Babu, Advaidhaa Nagarajan, Esha Narvekar, Raghavendra Upadhya, Ashok K Shetty |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |