Localized Proteomics of Amyloid Plaque Tissue in Down Syndrome and Alzheimer’s Disease
Mitchell Marta Ariza, Dominique Leitner, Jianina Suazo, Ana Giusti Pedrosa, Evgeny Kanshin, Beatrix Ueberheide, Juan Fortea, Alberto Lleo, Thomas Wisniewski · 2025
Read Localized Proteomics of Amyloid Plaque Tissue in Down Syndrome and Alzheimer’s Disease by Mitchell Marta Ariza, Dominique Leitner, Jianina Suazo, Ana Giusti Pedrosa, Evgeny Kanshin, Beatrix Ueberheide, Juan Fortea, Alberto Lleo, Thomas Wisniewski (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709662.txt.
Description
Mitchell Marta Ariza and eight co-authors compare the protein mix inside brain plaques across three forms of one disease, in a 2025 paper. People with Down syndrome almost always develop Alzheimer's disease, thanks to an extra copy of a key gene. Their plaques may still differ from those in early- and late-onset forms. The team cut plaque tissue from stored brains of 20 people per group and read its proteins, then did the same for nearby clean tissue.
Each group showed its own list of shifted proteins, well over a hundred per group. Only a small share of plaque proteins was common to all three forms. Plaque profiles from the Down syndrome group tracked the early-onset group most closely. Shared themes ran through all three: waste transport, immune work, and the cell's recycling bins. The maps give drug hunters fresh targets per form.
Catalog record
| CREATOR | Mitchell Marta Ariza, Dominique Leitner, Jianina Suazo, Ana Giusti Pedrosa, Evgeny Kanshin, Beatrix Ueberheide, Juan Fortea, Alberto Lleo, Thomas Wisniewski |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |