Alzheimer’s Disease Polygenic Risk in the LEADS Cohort
Kelly N Nudelman, Julian V Pentchev, Trever Jackson, Ani Eloyan, Jeffrey L Dage, Tatiana M Foroud, Dustin B Hammers, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, the LEADS Consortium · 2025
Read Alzheimer’s Disease Polygenic Risk in the LEADS Cohort by Kelly N Nudelman, Julian V Pentchev, Trever Jackson, Ani Eloyan, Jeffrey L Dage, Tatiana M Foroud, Dustin B Hammers, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, the LEADS Consortium (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709661.txt.
Description
Kelly Nudelman and co-authors ask whether the gene lottery for the common, late form of Alzheimer's also loads the dice for the rare early form. The LEADS study follows people whose disease begins young, before sixty-five. Their 2025 paper computes a polygenic risk score, the summed weight of thirty-one known risk variants, for 369 participants: early-onset patients, impaired patients without the Alzheimer's marker, and controls.
The hypothesis is that true early-onset cases carry heavier inherited risk from those common variants than the other groups. The team also tests whether the score predicts the age symptoms begin and how cognition fares within the patient group. Models adjust for age, sex, and ancestry. Whatever the answer, it disciplines a live question in genetics: whether early and late Alzheimer's are one disease at different speeds or partly different diseases sharing a name.
Catalog record
| CREATOR | Kelly N Nudelman, Julian V Pentchev, Trever Jackson, Ani Eloyan, Jeffrey L Dage, Tatiana M Foroud, Dustin B Hammers, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, the LEADS Consortium |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |