Polytranscriptomic risk score for Alzheimer Disease in a large diverse multi‐center brain bank study
Basilio Cieza, Zikun Yang, Dolly Reyes‐Dumeyer, Annie J. Lee, Brittany N Dugger, Lee‐Way Jin, Melissa E. Murray, Dennis W. Dickson, Margaret A Pericak‐Vance, Jeffery M. Vance, Tatiana M. Foroud, Richard Mayeux, Giuseppe Tosto · 2025
Read Polytranscriptomic risk score for Alzheimer Disease in a large diverse multi‐center brain bank study by Basilio Cieza, Zikun Yang, Dolly Reyes‐Dumeyer, Annie J. Lee, Brittany N Dugger, Lee‐Way Jin, Melissa E. Murray, Dennis W. Dickson, Margaret A Pericak‐Vance, Jeffery M. Vance, Tatiana M. Foroud, Richard Mayeux, Giuseppe Tosto (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709589.txt.
Description
Basilio Cieza and co-authors build, in a 2025 study, a risk score for Alzheimer's disease out of gene activity rather than gene variants. Static DNA scores miss much of the disease's heritability. Their score instead weighs how strongly candidate genes are expressed in the brain's prefrontal cortex. The candidates were picked by a random forest from five hundred sixty-five donated brains across six American brain banks.
The donors spanned white, Hispanic, and African American groups, deliberately. The score separated low from high pathology stages with accuracy near eighty percent, and, unusually, it held when trained on one ethnic group and tested on another. Checked in a second large cohort of over a thousand brains, it performed the same. The authors argue that expression-based scores, built diverse from the start, can travel across populations where DNA scores often fail.
Catalog record
| CREATOR | Basilio Cieza, Zikun Yang, Dolly Reyes‐Dumeyer, Annie J. Lee, Brittany N Dugger, Lee‐Way Jin, Melissa E. Murray, Dennis W. Dickson, Margaret A Pericak‐Vance, Jeffery M. Vance, Tatiana M. Foroud, Richard Mayeux, Giuseppe Tosto |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |