The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
Tovia Jacobs, Sean R Jacobson, Juan Fortea, Jeffrey S Berger, Alok Vedvyas, Karyn Marsh, Moses Gonzalez, Luisa F Figueredo, Chelsea Reichert Plaska, Esther M Blessing, Rebecca A Betensky, Henry Rusinek, Lidia Glodzik, Thomas Wisniewski, Ricardo S Osorio, Mony J de Leon, Jaime Ramos Cejudo, Alzheimer · 2025
Read The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people by Tovia Jacobs, Sean R Jacobson, Juan Fortea, Jeffrey S Berger, Alok Vedvyas, Karyn Marsh, Moses Gonzalez, Luisa F Figueredo, Chelsea Reichert Plaska, Esther M Blessing, Rebecca A Betensky, Henry Rusinek, Lidia Glodzik, Thomas Wisniewski, Ricardo S Osorio, Mony J de Leon, Jaime Ramos Cejudo, Alzheimer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709582.txt.
Description
Tovia Jacobs, Sean R Jacobson, and a large team of co-authors tested whether a simple blood ratio tracks Alzheimer's disease changes in people whose thinking is still normal. Their 2025 study uses the neutrophil to lymphocyte ratio, a marker of inflammation from a routine blood count. The ratio has been linked to Alzheimer's before, but it also rises in many other conditions that raise Alzheimer's risk.
The team compared the ratio with Alzheimer's biomarkers in spinal fluid in two groups of cognitively unimpaired older adults. Adjustments covered social factors, a key risk gene, and common illnesses. The question was whether the ratio links to the disease process itself or merely to the company it keeps. The answer matters for cheap early screening.
Catalog record
| CREATOR | Tovia Jacobs, Sean R Jacobson, Juan Fortea, Jeffrey S Berger, Alok Vedvyas, Karyn Marsh, Moses Gonzalez, Luisa F Figueredo, Chelsea Reichert Plaska, Esther M Blessing, Rebecca A Betensky, Henry Rusinek, Lidia Glodzik, Thomas Wisniewski, Ricardo S Osorio, Mony J de Leon, Jaime Ramos Cejudo, Alzheimer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |