Longterm Protective Effects of Complement C3 Lowering in Adult APP‐KI Mice
Brijendra Singh, Emma Spooner, Andre F Batista, Takaomi C Saido, Michael Carroll, Cynthia A Lemere · 2025
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Description
Brijendra Singh and five co-authors test a way to lower a blood protein called complement C3 in mice bred to build up amyloid in the brain. Their paper came out in twenty twenty-five. Past work found that mice born without C3 kept better thought and brain links with age, and this study asks if lowering C3 in adult mice helps too.
Treated mice had much less C3 in blood and brain. They did better on maze and object tests than mice given oil alone. Brain scans showed no change in total amyloid, but treated mice had less swelling near plaques and stronger links in one brain area. The team reads this as help for thought and brain links.
Catalog record
| CREATOR | Brijendra Singh, Emma Spooner, Andre F Batista, Takaomi C Saido, Michael Carroll, Cynthia A Lemere |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |