CAA and ARIA: Emerging Concepts and Opportunities for Translation
Steven M Greenberg · 2025
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Description
Steven Greenberg wrote this 2025 review on brain side effects of anti-amyloid treatment for Alzheimer's disease. The side effects, called ARIA, show as swelling or tiny bleeds on brain scans. Their cause is debated, and two broad mechanisms lead the field.
One idea says treatment sweeps antibody-bound amyloid from brain tissue into vessel walls, overloading them. The other says antibodies strike amyloid already lodged in vessels, the condition called cerebral amyloid angiopathy. Mouse models and a look-alike spontaneous illness back the second idea. Scans taken before treatment show that prior microbleeds predict later ARIA, which also fits the vessel story. Greenberg weighs what each path would mean for safer treatment design.
Catalog record
| CREATOR | Steven M Greenberg |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |