Association Between Age and Cognitive Severity in Early‐Onset AD: Extension of preliminary findings in the Longitudinal Early‐Onset Alzheimer’s Disease Study (LEADS)
Dustin B Hammers, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Kala Kirby, Bonnie Wong, Jeffrey L Dage, Kelly N Nudelman, Maria C Carrillo, Gil D Rabinovici, Bradford C Dickerson, Liana G Apostolova, LEADS Consortium · 2025
Read Association Between Age and Cognitive Severity in Early‐Onset AD: Extension of preliminary findings in the Longitudinal Early‐Onset Alzheimer’s Disease Study (LEADS) by Dustin B Hammers, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Kala Kirby, Bonnie Wong, Jeffrey L Dage, Kelly N Nudelman, Maria C Carrillo, Gil D Rabinovici, Bradford C Dickerson, Liana G Apostolova, LEADS Consortium (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709507.txt.
Description
Dustin Hammers led a large team studying early-onset Alzheimer's disease in a 2025 paper. They asked whether age at entry links to how severe thinking problems are. Past work in the same study hinted that younger patients fare worse, but it was unclear whether that pattern holds for other early-onset conditions.
They used baseline test data from hundreds of participants in three groups: early Alzheimer's, other early impairment, and healthy peers. Age linked to executive function differently by group. In the Alzheimer's group, older age at entry went with better scores, while healthy peers showed the reverse. The authors controlled for sex, schooling, gene status, and disease severity.
Catalog record
| CREATOR | Dustin B Hammers, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Kala Kirby, Bonnie Wong, Jeffrey L Dage, Kelly N Nudelman, Maria C Carrillo, Gil D Rabinovici, Bradford C Dickerson, Liana G Apostolova, LEADS Consortium |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |