Neuronal Cell‐Type Susceptibility in the Ventral Subiculum of 5xFAD Mice
Maricarmen Pachicano, Neda Khanjani, Angela Hurtado, Shrey Mehta, Zion MK Smith, Michael S Bienkowski · 2025
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Description
Alzheimer's disease does not kill brain cells evenly, and Maricarmen Pachicano and co-authors ask which residents of one early-hit region, the ventral subiculum, fall first. In the 5xFAD mouse, this hippocampal exit zone loses many cells by eight months. Using a gene-expression atlas that fingerprints its cell types, they label single RNA molecules in tissue from young and old, sick and healthy mice.
Counting labeled cells type by type across the disease course reveals which populations resist and which crumble. Such a susceptibility map, the team argues, is the kind of knowledge targeted treatments must be built on, rather than treating the region as uniform.
Catalog record
| CREATOR | Maricarmen Pachicano, Neda Khanjani, Angela Hurtado, Shrey Mehta, Zion MK Smith, Michael S Bienkowski |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |