Subtype‐specific patterns of tau pathology in Alzheimer’s and related disorders
Diana A Hobbs, Stephanie Doering, Austin A. McCullough, Peter R Millar, Shaney Flores, Sarah J. Keefe, Aristeidis Sotiras, Tammie L.S. Benzinger, Gregory S Day, Brian A. Gordon · 2025
Read Subtype‐specific patterns of tau pathology in Alzheimer’s and related disorders by Diana A Hobbs, Stephanie Doering, Austin A. McCullough, Peter R Millar, Shaney Flores, Sarah J. Keefe, Aristeidis Sotiras, Tammie L.S. Benzinger, Gregory S Day, Brian A. Gordon (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709391.txt.
Description
Diana Hobbs and nine co-authors compare tau deposit patterns across typical Alzheimer's disease and two atypical variants, one attacking vision and one attacking language. Their study came out in 2025. Tau scans were mapped against nine biological properties of the cortex.
Across all three groups, tau accumulated most where the cortex had expanded most over evolution, and vessel health tracked tau strongly. Beyond that shared pattern, the variants diverged: gene expression and myelin related to tau differently in each. The vision variant tied tau to cortical thickness in the opposite direction from the others. The authors say these fingerprints can explain why the same disease presents so differently, and may guide variant-specific research.
Catalog record
| CREATOR | Diana A Hobbs, Stephanie Doering, Austin A. McCullough, Peter R Millar, Shaney Flores, Sarah J. Keefe, Aristeidis Sotiras, Tammie L.S. Benzinger, Gregory S Day, Brian A. Gordon |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |