A novel coumarin derivative treatment ameliorates neuroinflammation and cognitive functions in the ICV‐STZ‐induced rat model of Alzheimer’s disease
PRAJJWAL SHARMA · 2025
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Description
Prajjwal Sharma tests a plant-derived compound in a rat model of Alzheimer's disease in a 2025 study. Brain inflammation helps drive the disease, and platelets carry most of the amyloid protein circulating in blood. The compound, a new coumarin derivative called PS21HKR, was chosen for its promise against platelets and inflammation. Rats received a toxin injection into the brain's ventricles to mimic the disease, then the compound or no treatment.
Treated rats performed better on behavior tests of cognition. A bleeding-time test confirmed the action on platelets, and cell studies showed the compound shifting markers of inflammation. Animal and dish results together make a case, though a long road separates rat relief from a human medicine.
Catalog record
| CREATOR | PRAJJWAL SHARMA |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |