Ancestry‐specific studies on Alzheimer’s disease using iPSC‐derived microglia
Sofia Moura, Luciana Bertholim Nasciben, Jihanne J Shepherd, Lauren Coombs, Aura M Ramirez, Shaina A Simon, Derek Van Booven, Joe Rivero, Brooke A DeRosa, Patrice L Whitehead, Larry D Adams, Takiyah D Starks, Pedro R Mena, Maryenela Z Illanes‐Manrique, Sergio J Tejada, Goldie S Byrd, Mario Cornejo‐O · 2025
Read Ancestry‐specific studies on Alzheimer’s disease using iPSC‐derived microglia by Sofia Moura, Luciana Bertholim Nasciben, Jihanne J Shepherd, Lauren Coombs, Aura M Ramirez, Shaina A Simon, Derek Van Booven, Joe Rivero, Brooke A DeRosa, Patrice L Whitehead, Larry D Adams, Takiyah D Starks, Pedro R Mena, Maryenela Z Illanes‐Manrique, Sergio J Tejada, Goldie S Byrd, Mario Cornejo‐O (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709373.txt.
Description
Sofia Moura and a large team of co-authors study Alzheimer's disease in 2025 using lab-grown immune cells of the brain. In the United States, Black and Hispanic groups face higher rates of the disease than non-Hispanic White groups. Most past work focused on the last group.
The team grew microglia from stem cells of donors with African, Amerindian, and European ancestry. They measured gene activity and gene access in the cells. More than a thousand genes differed in activity across groups. The work aims to reveal ancestry-linked paths that may shape disease risk.
Catalog record
| CREATOR | Sofia Moura, Luciana Bertholim Nasciben, Jihanne J Shepherd, Lauren Coombs, Aura M Ramirez, Shaina A Simon, Derek Van Booven, Joe Rivero, Brooke A DeRosa, Patrice L Whitehead, Larry D Adams, Takiyah D Starks, Pedro R Mena, Maryenela Z Illanes‐Manrique, Sergio J Tejada, Goldie S Byrd, Mario Cornejo‐O |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |