The anti‐platelet agent prasugrel reverses the cerebral blood flow deficit and memory impairment induced by hypertension in ApoE4‐positive mice
Lianne J Trigiani, Nicole E Chernavsky, Rachel Kim, Robert F Hawkins, Nuri Hong, Keri Yamaguchi, Jonah Bernard, Amanda Huang, Gina H Bae, Daniel A Rivera, Nathaniel Allan‐Rahill, Michael Lamont, Costantino Iadecola, Nozomi Nishimura, Chris B Schaffer · 2025
Read The anti‐platelet agent prasugrel reverses the cerebral blood flow deficit and memory impairment induced by hypertension in ApoE4‐positive mice by Lianne J Trigiani, Nicole E Chernavsky, Rachel Kim, Robert F Hawkins, Nuri Hong, Keri Yamaguchi, Jonah Bernard, Amanda Huang, Gina H Bae, Daniel A Rivera, Nathaniel Allan‐Rahill, Michael Lamont, Costantino Iadecola, Nozomi Nishimura, Chris B Schaffer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709371.txt.
Description
Lianne Trigiani and fourteen co-authors test whether a blood-thinning drug can rescue brain blood flow and memory in mice carrying the strongest genetic risk factor for Alzheimer's disease. Their study came out in 2025. The mice were also made hypertensive, since high blood pressure compounds the risk.
Under high blood pressure, the risk-gene mice lost memory performance while tiny brain capillaries slowed and stalled more often. Most stalls were plugs of red blood cells. A week of the anti-platelet drug prasugrel cut stalling by more than half and restored flow. Memory performance recovered with it, and the blood-brain barrier looked healthier. The authors propose anti-platelet treatment as a candidate strategy where these two risk factors combine.
Catalog record
| CREATOR | Lianne J Trigiani, Nicole E Chernavsky, Rachel Kim, Robert F Hawkins, Nuri Hong, Keri Yamaguchi, Jonah Bernard, Amanda Huang, Gina H Bae, Daniel A Rivera, Nathaniel Allan‐Rahill, Michael Lamont, Costantino Iadecola, Nozomi Nishimura, Chris B Schaffer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |