Functional assessment of Phospholipase D1 using wild‐type, transgenic AD mice, and human spheroid models: A spatial and temporal mechanism for the progression of neurodegeneration
Sravan Gopalkrishna Shetty Sreenivasa Murthy, Chandramouli Natarajan, Klarissa H Garza, Shaneilahi M Budhwani, Sarah Bosworth, Joshua Currie, Sanjana Mohanty, Malav S Mallipudi, Kyle S Sheth, Evan Wong, Poonam Shah, Thomas A Green, Marlene E Villarreal Juarez, Agenor Limon, Emily Lee, Jiajing Zhang, · 2025
Read Functional assessment of Phospholipase D1 using wild‐type, transgenic AD mice, and human spheroid models: A spatial and temporal mechanism for the progression of neurodegeneration by Sravan Gopalkrishna Shetty Sreenivasa Murthy, Chandramouli Natarajan, Klarissa H Garza, Shaneilahi M Budhwani, Sarah Bosworth, Joshua Currie, Sanjana Mohanty, Malav S Mallipudi, Kyle S Sheth, Evan Wong, Poonam Shah, Thomas A Green, Marlene E Villarreal Juarez, Agenor Limon, Emily Lee, Jiajing Zhang, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11709369.txt.
Description
A large team led by Sravan Gopalkrishna Shetty Sreenivasa Murthy studies a fat-cutting protein called PLD1 in mouse and human cell models of Alzheimer's disease. The work appeared in twenty twenty-five. Past lab work found too much PLD1 in brain tissue from people who died with the disease. This study tracks where and when PLD1 acts as harm grows.
Mice got a drug that blocks PLD1, or a virus used to change PLD1 in set brain areas. The team then ran maze and object tests for learning and memory. They also checked brain cell links with electric tests and stained tissue views. Readers get a close look at how one protein may drive loss of brain links over time.
Catalog record
| CREATOR | Sravan Gopalkrishna Shetty Sreenivasa Murthy, Chandramouli Natarajan, Klarissa H Garza, Shaneilahi M Budhwani, Sarah Bosworth, Joshua Currie, Sanjana Mohanty, Malav S Mallipudi, Kyle S Sheth, Evan Wong, Poonam Shah, Thomas A Green, Marlene E Villarreal Juarez, Agenor Limon, Emily Lee, Jiajing Zhang, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |