Thrombopoietic agents enhance bone healing in mice, rats, and pigs
Paul J Childress, Jeffery J Nielsen, Thomas B Bemenderfer, Ushashi C Dadwal, Nabarun Chakraborty, Jonathan S Harris, Monique Bethel, Marta B Alvarez, Aamir Tucker, Alexander R Wessel, Patrick D Millikan, Jonathan H Wilhite, Andrew Engle, Alexander Brinker, Jeffrey D Rytlewski, David C Scofield, Kait · 2025
Read Thrombopoietic agents enhance bone healing in mice, rats, and pigs by Paul J Childress, Jeffery J Nielsen, Thomas B Bemenderfer, Ushashi C Dadwal, Nabarun Chakraborty, Jonathan S Harris, Monique Bethel, Marta B Alvarez, Aamir Tucker, Alexander R Wessel, Patrick D Millikan, Jonathan H Wilhite, Andrew Engle, Alexander Brinker, Jeffrey D Rytlewski, David C Scofield, Kait (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11700610.txt.
Description
Childress and a large team show that platelet growth drugs speed bone healing in mice, rats, and pigs in twenty twenty-four. Broken bones that refuse to knit remain a clinical headache. The usual growth proteins carry side effect worries, including cancer links. Thrombopoietin, the marrow signal for platelet making cells, was their candidate.
Two fracture models and both local and body wide dosing worked. Gene and cell studies credit richer blood vessel growth for the gain. Vessel growth is a must for bone union. The drugs already serve clinic use for low platelets, with known safety. That head start lifts their promise here.
Catalog record
| CREATOR | Paul J Childress, Jeffery J Nielsen, Thomas B Bemenderfer, Ushashi C Dadwal, Nabarun Chakraborty, Jonathan S Harris, Monique Bethel, Marta B Alvarez, Aamir Tucker, Alexander R Wessel, Patrick D Millikan, Jonathan H Wilhite, Andrew Engle, Alexander Brinker, Jeffrey D Rytlewski, David C Scofield, Kait |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |