An oncolytic HAdV-5 with reduced surface charge combines diminished toxicity and improved tumor targeting
Frederik Wienen, Robin Nilson, Ellen Allmendinger, Sarah Peters, Thomas FE Barth, Stefan Kochanek, Lea Krutzke · 2024
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Description
Frederik Wienen and co-authors retune a cancer-killing virus so it hits tumors harder and the liver less. The virus is a modified adenovirus that infects and bursts cancer cells. Off-target liver uptake has limited such drugs and risks liver damage.
The team changed the virus's main shell protein to cut its negative surface charge. They also removed its normal cell-entry route, forcing new paths in. The remade virus entered many cancer cell lines better than the parent, even without its usual receptor. In tumor-bearing mice, the particles reached tumors with less liver spill. Plasma from virus-naive mice boosted entry further. Safer targeting could widen the dose window for patients.
Catalog record
| CREATOR | Frederik Wienen, Robin Nilson, Ellen Allmendinger, Sarah Peters, Thomas FE Barth, Stefan Kochanek, Lea Krutzke |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |