Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice
Jaspreet Jain, Tram N.Q. Pham, Sharmin Begum, Maria Carmen Romero-Medina, Nicolas Bellini, Yuanyi Li, Frédéric Dallaire, Kathie Béland, Natasha Patey, Jean V. Guimond, Élie Haddad, Yifan Zhai, Éric A. Cohen · 2024
Read Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice by Jaspreet Jain, Tram N.Q. Pham, Sharmin Begum, Maria Carmen Romero-Medina, Nicolas Bellini, Yuanyi Li, Frédéric Dallaire, Kathie Béland, Natasha Patey, Jean V. Guimond, Élie Haddad, Yifan Zhai, Éric A. Cohen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11699618.txt.
Description
Jaspreet Jain and co-authors tested a drug that may flush out hidden HIV in humanized mice for a 2024 paper. HIV can sit latent in cells, and those reservoirs block a cure. The drug, a two armed SMAC mimetic, wakes latent virus in cell models and pushes infected cells toward death. The team tested it in lab infected immune cells and in mice built with human immune systems.
In lab cells, the drug cut latently infected cells while sparing cells with active virus. In virus suppressed mice, it raised viral RNA inside cells and sharply cut cells holding HIV DNA, without stirring up the immune system broadly. When treatment was paused, virus rebound was lower in treated mice, and virus levels stayed below pre treatment values. The authors present drugs of this class as candidates for HIV cure strategies.
Catalog record
| CREATOR | Jaspreet Jain, Tram N.Q. Pham, Sharmin Begum, Maria Carmen Romero-Medina, Nicolas Bellini, Yuanyi Li, Frédéric Dallaire, Kathie Béland, Natasha Patey, Jean V. Guimond, Élie Haddad, Yifan Zhai, Éric A. Cohen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |