Nuclear transmembrane protein 199 promotes immune escapes by up-regulating programmed death ligand 1
Wulin You, Hue Luu, Meili Li, Zhiyu Chen, Fangchao Li, Yanfei Zhang, Mingsheng Cai, Tong-chuan He, Jingjing Li · 2024
Read Nuclear transmembrane protein 199 promotes immune escapes by up-regulating programmed death ligand 1 by Wulin You, Hue Luu, Meili Li, Zhiyu Chen, Fangchao Li, Yanfei Zhang, Mingsheng Cai, Tong-chuan He, Jingjing Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11699465.txt.
Description
Wulin You and eight co-authors show that a little-studied membrane protein helps tumors hide from the immune system. Their twenty twenty-four article studies TMEM199, which they find sitting in the cell nucleus, not just in membranes. In the nucleus it touches the machinery that controls PD-L1, a shield protein cancers use to switch off immune attack.
Through a global binding assay, the team shows nuclear TMEM199 binds several transcription factors that switch on the PD-L1 gene. That binding raises PD-L1 levels in lab and animal tests, which helps the tumor escape immunity. The work names a new role for this protein in cancer growth and a possible drug target.
Catalog record
| CREATOR | Wulin You, Hue Luu, Meili Li, Zhiyu Chen, Fangchao Li, Yanfei Zhang, Mingsheng Cai, Tong-chuan He, Jingjing Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |