A Nanotheranostic Agent for Synergistic Antitumor Chemo/Phototherapy Prepared by Paclitaxel-Induced Self-Assembly of PEGylated Human Serum Albumin with Prolonged Circulation
Changsong Liu, Wenjia Xu, Xinlei Song, Weilu Tian, Fuyan Liu, Fengshan Wang · 2024
Read A Nanotheranostic Agent for Synergistic Antitumor Chemo/Phototherapy Prepared by Paclitaxel-Induced Self-Assembly of PEGylated Human Serum Albumin with Prolonged Circulation by Changsong Liu, Wenjia Xu, Xinlei Song, Weilu Tian, Fuyan Liu, Fengshan Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11696392.txt.
Description
Changsong Liu, Wenjia Xu, Xinlei Song, Weilu Tian, Fuyan Liu, and Fengshan Wang present a 2024 study on a nanoparticle that treats tumors with drugs and light together. Albumin, a blood protein, carries drugs well but its particles break down fast in circulation. The team stabilized it by attaching a polymer chain at one precise site.
A chemotherapy drug, paclitaxel, both fights the tumor and triggers the particles to self-assemble. A near-infrared dye joins for light therapy and imaging. The longer polymer version formed more uniform particles with better drug loading than the short one. It also reached tumors more effectively and stayed in the blood longer, without blocking cell uptake. The design aims at combined treatment with fewer side effects.
Catalog record
| CREATOR | Changsong Liu, Wenjia Xu, Xinlei Song, Weilu Tian, Fuyan Liu, Fengshan Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |