Larval hematopoietic organs of multiple Drosophila species show effector caspase activity and DNA damage response
Deepak Maurya, Bama Charan Mondal · 2024
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Description
Deepak Maurya and Bama Charan Mondal report in 2024 that blood-forming organs in several fruit fly species share a conserved developmental mechanism. In the common fruit fly, a burst of caspase activity triggers a DNA damage response that helps create macrophage-type blood cells. Other species have lymph glands of different sizes, raising the question of conservation.
The authors find the same caspase activity and DNA damage response in those other species. The pattern matches the well-studied species closely. That suggests the mechanism that drives phagocytic cell development is conserved across the genus. The short report adds comparative evidence to fly blood biology.
Catalog record
| CREATOR | Deepak Maurya, Bama Charan Mondal |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |