APEX-based proximity labeling in Plasmodium identifies a membrane protein with dual functions during mosquito infection
Jessica Kehrer, Emma Pietsch, Dominik Ricken, Léanne Strauss, Julia M. Heinze, Tim Gilberger, Friedrich Frischknecht, Kirk W. Deitsch, Margaret A Phillips, Kirk W. Deitsch, Margaret A Phillips, Kirk W. Deitsch, Margaret A Phillips · 2024
Read APEX-based proximity labeling in Plasmodium identifies a membrane protein with dual functions during mosquito infection by Jessica Kehrer, Emma Pietsch, Dominik Ricken, Léanne Strauss, Julia M. Heinze, Tim Gilberger, Friedrich Frischknecht, Kirk W. Deitsch, Margaret A Phillips, Kirk W. Deitsch, Margaret A Phillips, Kirk W. Deitsch, Margaret A Phillips (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11695019.txt.
Description
Jessica Kehrer and a team of co-authors use a tagging enzyme to inventory the proteins a malaria parasite fires during mosquito infection. Their study appeared in twenty twenty-four. Blocking that handoff to mosquitoes is a prime route to stopping malaria's spread.
The team worked in a rodent malaria species. A rapid labeling method marked proteins inside tiny sacs of the invasive stage that pierces the mosquito gut. Over fifty new candidates joined the known list, and the catalog grew sharper than an older survey. One membrane protein was tested in depth. It serves twice: helping male gametes form and helping the invader cross the gut. A small change in its tail broke only the second job.
Catalog record
| CREATOR | Jessica Kehrer, Emma Pietsch, Dominik Ricken, Léanne Strauss, Julia M. Heinze, Tim Gilberger, Friedrich Frischknecht, Kirk W. Deitsch, Margaret A Phillips, Kirk W. Deitsch, Margaret A Phillips, Kirk W. Deitsch, Margaret A Phillips |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |