MITOCHONDRIAL DYSFUNCTION IN DYSREGULATED MONOCYTE IMMUNE RESPONSE
Rafael Moura Maurmann, Brandt D Pence · 2024
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Description
Rafael Moura Maurmann and Brandt Pence wrote a 2024 paper on the power plants of immune cells in older people. Monocytes are front-line immune cells whose responses grow erratic with age, with more background inflammation. Their mitochondria, the cell's energy makers, also falter with age. The team tested whether the two faults are linked.
They used a human monocyte cell line and damaged its mitochondria with a drug, with and without a blocker of the cell's recycling system. A stress test then measured how the cells breathed and made energy. Damage alone cut the cells' top breathing capacity. Models like this let researchers test whether fixing cell power plants can calm the inflammation of aging.
Catalog record
| CREATOR | Rafael Moura Maurmann, Brandt D Pence |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |