THE NEUTROPHIL-LYMPHOCYTE RATIO AND WHITE BLOOD CELL COUNT ASSOCIATE WITH MUSCLE ENERGETICS AND GAIT SPEED IN SOMMA
Philip Kramer, Peggy Cawthon, Li-Yung Lui, Theodore DeConne, Nancy Lane, Xiaoyan Leng, Anne Newman, Stephen Kritchevsky · 2024
Read THE NEUTROPHIL-LYMPHOCYTE RATIO AND WHITE BLOOD CELL COUNT ASSOCIATE WITH MUSCLE ENERGETICS AND GAIT SPEED IN SOMMA by Philip Kramer, Peggy Cawthon, Li-Yung Lui, Theodore DeConne, Nancy Lane, Xiaoyan Leng, Anne Newman, Stephen Kritchevsky (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11690369.txt.
Description
Philip Kramer and colleagues link simple blood inflammation markers to muscle energy production and walking speed in older adults. Systemic inflammation drives sarcopenia and cachexia, which erode mobility and independence. Muscle mitochondrial energetics are strongly tied to gait speed and leg power, but how much systemic inflammation contributes to weaker muscle energetics was not fully understood.
In the Study of Muscle, Mobility and Aging, the team measured the neutrophil-lymphocyte ratio and total white blood cell count in adults spanning a wide age range. Participants with higher inflammation ratios had significantly lower maximal muscle energetics and slower four-hundred-meter gait speed, alongside greater multimorbidity and older age. The associations were partly explained by age and body mass index, and weakened further under full adjustment. The results position cheap blood markers as partial windows on muscle health, while cautioning that inflammation is only one strand of the aging muscle story.
Catalog record
| CREATOR | Philip Kramer, Peggy Cawthon, Li-Yung Lui, Theodore DeConne, Nancy Lane, Xiaoyan Leng, Anne Newman, Stephen Kritchevsky |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |