NEW TOOL ENHANCES DETECTION OF LIFE-EXTENDING INTERVENTIONS BY DELINEATING THEIR TEMPORAL EFFICACY
Nisi Jiang, Qianqian Liu, Catherine Cheng, Randy Strong, Jonathan Gelfond, James Nelson · 2024
Read NEW TOOL ENHANCES DETECTION OF LIFE-EXTENDING INTERVENTIONS BY DELINEATING THEIR TEMPORAL EFFICACY by Nisi Jiang, Qianqian Liu, Catherine Cheng, Randy Strong, Jonathan Gelfond, James Nelson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11690145.txt.
Description
Nisi Jiang and five co-authors introduce a new tool to judge drugs that may extend life, in work from 2024. Tests of aging drugs rely on survival data that take long to collect and cost a lot. The standard test says if a drug helps overall, but not when it helps or for how long.
Their tool builds a time profile of benefit or harm across the full life span. They tried it on survival data for 42 compounds tested in mice. The tool found more than twice as many helpful or harmful effects as the standard test. Gains and harms often differed by sex and faded or grew with age.
Catalog record
| CREATOR | Nisi Jiang, Qianqian Liu, Catherine Cheng, Randy Strong, Jonathan Gelfond, James Nelson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |