GLYNAC SUPPLEMENTATION IN OLDER ADULTS IMPROVES GLUTATHIONE, MITOCHONDRIA, AGING HALLMARKS, AND FUNCTION
Rajagopal Sekhar, Premranjan Kumar, George Taffet, Charles Minard, James Suliburk, Farook Jahoor, Chun Liu, Raja Muthupillai · 2024
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Description
Rajagopal Sekhar and a team of co-authors report that a two-part supplement reversed several aging defects in older adults. Their trial appeared in twenty twenty-four. The supplement, called GlyNAC, pairs glycine with a cysteine donor to rebuild glutathione, the cell's main antioxidant.
Twenty-four older adults took GlyNAC or placebo for sixteen weeks, with twelve young adults as a comparison. At the start, the older group showed glutathione shortage, high oxidative stress, sluggish fat burning in mitochondria, and insulin resistance. Walking speed, strength, and endurance also lagged. Supplementation, unlike placebo, corrected the antioxidant shortage and eased the stress markers. The trial extends earlier mouse results into people. Functional gains accompanied the molecular repairs.
Catalog record
| CREATOR | Rajagopal Sekhar, Premranjan Kumar, George Taffet, Charles Minard, James Suliburk, Farook Jahoor, Chun Liu, Raja Muthupillai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |