METFORMIN AS A POTENTIAL PHARMACOLOGIC INTERVENTION TO IMPROVE HEALTHSPAN
Sara Espinoza · 2024
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Description
Espinoza reviews metformin as a candidate drug to stretch healthspan, the years lived in good health. Metformin is the most used oral diabetes drug and a first-line choice. In animal models it lengthens life, and human records link it to less cancer and heart disease.
Records also tie it to less dementia, frailty, and death overall. The drug is safe, well tolerated, and already widely used, which fuels interest. It switches on AMPK and touches many aging hallmarks, from gene marks to gut microbes. Few trials test healthspan directly. One ongoing trial checks frailty prevention in older adults.
Catalog record
| CREATOR | Sara Espinoza |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |