LIMITATIONS OF POLYGENIC RISK SCORES FOR DEMENTIA IN FAMILIAL EXCEPTIONAL AGING: IMPACT OF SAMPLING
Laura Xicota, Rong Cheng, Sandra Barral Rodriguez, Lawrence Honig, Joseph Lee · 2024
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Description
Laura Xicota, Rong Cheng, Sandra Barral Rodriguez, Lawrence Honig, and Joseph Lee test gene risk scores for dementia in long lived families in a 2024 study. Scores built from many small gene risks flag high risk people in the broad public. Families with extreme long life run low dementia risk, which makes a sharp test case.
Scores built from two large public gene hunts did not predict dementia in the US arm of the family study. Risk gene forms were just as common there, but they lacked their usual effect. Just 6.7% and 7.7% of the gene spots tied to disease in that group. Blood markers of brain harm also failed to rise with the scores. The work warns that public risk scores may not travel to such groups.
Catalog record
| CREATOR | Laura Xicota, Rong Cheng, Sandra Barral Rodriguez, Lawrence Honig, Joseph Lee |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |