GENES, LIPIDS, AND ALZHEIMER DISEASE RISK IN FAMILIES WITH EXCEPTIONAL LONGEVITY
Rong Cheng, Laura Xicota, Sandra Barral Rodriguez, Lawrence Honig, Gary Patti, Joseph Lee · 2024
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Description
Families who live to very old ages offer clues about why some brains resist Alzheimer's disease. Rong Cheng and co-authors mine those clues in a 2024 study of a long life family cohort in the United States. They combined genome, gene activity, and blood fat data from just over three thousand people.
Of 188 fats measured, 18 were strongly inherited and tied to Alzheimer's risk. The genome search landed on two regions, one packed with fat-handling genes. Two outside cohorts, one general and one of adults with Down syndrome, helped check the findings. The work maps a path from genes to blood fats to brain risk, which may reveal new ways to lower that risk.
Catalog record
| CREATOR | Rong Cheng, Laura Xicota, Sandra Barral Rodriguez, Lawrence Honig, Gary Patti, Joseph Lee |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |