DISSECTING THE HETEROGENEITY OF SENESCENCE: PROFILING PRIMARY AND SECONDARY SENESCENT STATES USING SINGLE-CELL AND SPATIAL TRANSCRIPTOMICS
Nicola Neretti · 2024
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Description
Nicola Neretti studies, in twenty twenty-four, how cells that have stopped dividing differ from one another. Such cells build up with age and harm tissue. They give off a mix of signals that can cause swelling nearby. Some cells enter this state first. They can then push nearby cells into a second form of the same state.
Neretti tracks both forms over time, cell by cell, in the early phase. A machine learning tool sorts cells into the first form and kinds of the second form. The work compares that tool with older methods. It also shows how to spot such cells in the aging mouse liver.
Catalog record
| CREATOR | Nicola Neretti |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |