AGE TRAJECTORIES OF LYSOPHOSPHATIDYLCHOLINES IN RELATION TO ALZHEIMER’S DISEASE: FINDINGS FROM LLFS
Konstantin Arbeev, Olivia Bagley, Svetlana Ukraintseva, Stephanie Cosentino, Alexander Kulminski, Eric Stallard, Anatoliy Yashin · 2024
Read AGE TRAJECTORIES OF LYSOPHOSPHATIDYLCHOLINES IN RELATION TO ALZHEIMER’S DISEASE: FINDINGS FROM LLFS by Konstantin Arbeev, Olivia Bagley, Svetlana Ukraintseva, Stephanie Cosentino, Alexander Kulminski, Eric Stallard, Anatoliy Yashin (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11689300.txt.
Description
A family of fat molecules in the blood shifts with age, and a 2024 study by Konstantin Arbeev and co-authors asks how those shifts track Alzheimer's risk. The molecules, called LPCs, play roles in cell death and nerve insulation damage, and they have been floated as early warning markers.
Data came from a long-running family study of long-lived people in the United States. Nearly three thousand participants gave over four thousand measurements across twenty-three LPC types, with ninety-three cases of Alzheimer's arising during follow-up. Models that join repeated measures with time-to-disease found a male-only link between LPC paths and disease, after adjusting for age, schooling, smoking, medicines, and ancestry markers. One LPC type stood out most strongly.
Catalog record
| CREATOR | Konstantin Arbeev, Olivia Bagley, Svetlana Ukraintseva, Stephanie Cosentino, Alexander Kulminski, Eric Stallard, Anatoliy Yashin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |