ASSOCIATION OF PHYSICAL ACTIVITY WITH NEUROFILAMENT LIGHT IN NONDEMENTIA OLDER ADULTS AND THE MEDIATION OF FRAILTY
Sofia Liu, Mengchi Li, Miranda McPhillips, Russell Calderon, Junxin Li · 2024
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Description
Sofia Liu and co-authors wrote this 2024 study of movement, frailty, and a blood marker of nerve damage in older adults. Neurofilament light rises when neurons are injured, and it climbs with age. Activity is known to protect aging bodies, but its link to this brain marker was unclear.
The team studied 95 community-dwelling adults without dementia, average age seventy. Wrist sensors and questionnaires measured activity; a standard phenotype graded frailty; blood tests gave the marker levels. More sensor-measured activity went with lower marker levels. Frail participants carried far higher levels than robust or pre-frail ones. Frailty also statistically carried part of the activity effect. The findings sketch a path from movement to nerve health through physical resilience.
Catalog record
| CREATOR | Sofia Liu, Mengchi Li, Miranda McPhillips, Russell Calderon, Junxin Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |