MITOCHONDRIA, METABOLISM, AND GLUTATHIONE AS MEDIATORS OF COGNITIVE DECLINE IN AGING AND ALZHEIMER’S DISEASE
Rajagopal Sekhar, George Taffet · 2024
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Description
Rajagopal Sekhar and George Taffet introduce a symposium on why the aging brain loses energy and clarity. The brain burns more energy than any other organ, and its engines, the mitochondria, falter with age. At the same time, the protective molecule glutathione runs low, glucose handling slips, and inflammation rises. The talks connect these defects in aging and in Alzheimer disease.
One speaker reports weak energy production in patient mitochondria. Another links the same trio of defects to memory decline in old mice, and shows that a supplement called GlyNAC, which rebuilds glutathione, reversed them. A third presents a human trial where the supplement improved thinking and repaired metabolic flaws in older adults. The discussant adds data from ninety-one people placing glutathione shortage at the center of Alzheimer disease. The session frames energy failure as a treatable driver, not just a symptom, of cognitive decline.
Catalog record
| CREATOR | Rajagopal Sekhar, George Taffet |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |