TP53 oncogenic variants as prognostic factors in individuals with glioblastoma: a systematic review and meta-analysis
Diego Esperante, Kena Daza Galicia, Kalu Gabriel Rivas-Cuervo, Bernardo Cacho-Díaz, Catalina Trejo-Becerril, Lucia Taja-Chayeb, Orwa Aboud, José Alberto Carlos-Escalante, Talia Wegman-Ostrosky · 2024
Read TP53 oncogenic variants as prognostic factors in individuals with glioblastoma: a systematic review and meta-analysis by Diego Esperante, Kena Daza Galicia, Kalu Gabriel Rivas-Cuervo, Bernardo Cacho-Díaz, Catalina Trejo-Becerril, Lucia Taja-Chayeb, Orwa Aboud, José Alberto Carlos-Escalante, Talia Wegman-Ostrosky (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11688405.txt.
Description
Diego Esperante and eight colleagues pool the evidence on whether mutations in the TP53 gene predict how long glioblastoma patients live, in a systematic review and meta-analysis published in two thousand twenty-four. Glioblastoma is the most aggressive common brain tumor, and any reliable prognostic marker would help doctors plan and counsel.
The review searched multiple databases for longitudinal studies and trials with at least forty adults whose tumors sat in the upper brain and whose TP53 status was known. Twenty-three papers covering over two and a half thousand patients met the bar. The authors rated the risk of bias with a prognosis-specific tool and graded the certainty of evidence. They then combined overall survival and progression-free survival results across studies. Whether its variants carry weight in this tumor is a narrower question, and this synthesis answers it with the full literature.
Catalog record
| CREATOR | Diego Esperante, Kena Daza Galicia, Kalu Gabriel Rivas-Cuervo, Bernardo Cacho-Díaz, Catalina Trejo-Becerril, Lucia Taja-Chayeb, Orwa Aboud, José Alberto Carlos-Escalante, Talia Wegman-Ostrosky |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |