The synthesis of the novel Escherichia coli toxin—colibactin and its mechanisms of tumorigenesis of colorectal cancer
Guojing Zhang, Daqing Sun · 2024
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Description
Guojing Zhang and Daqing Sun review how a toxin made by a common gut bacterium may drive bowel cancer. Most strains of the bacterium help the gut. One group carries a gene island that builds the toxin, called colibactin.
The review walks through the island's genes and the steps of toxin assembly. The toxin damages host DNA in set patterns. Those patterns include single-letter changes and small insertions and deletions, marks also found in human bowel tumors. The match is the core of the cancer case. The authors gather what is known and what remains murky about the pathway. If the link firms up, screening stools for the island could join cancer prevention.
Catalog record
| CREATOR | Guojing Zhang, Daqing Sun |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |