High cumulative glucocorticoid dose is associated with increased levels of inflammation-related mediators in active rheumatoid arthritis
Anna Petrackova, Pavel Horak, Jakub Savara, Martina Skacelova, Eva Kriegova · 2024
Read High cumulative glucocorticoid dose is associated with increased levels of inflammation-related mediators in active rheumatoid arthritis by Anna Petrackova, Pavel Horak, Jakub Savara, Martina Skacelova, Eva Kriegova (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11688219.txt.
Description
Anna Petrackova and co-authors link high lifetime steroid doses to stronger inflammation signals in rheumatoid arthritis, in a 2024 study. Steroid drugs are a mainstay for this joint disease. Years of use pile up large total doses. What that history does to the body's inflammatory state was poorly understood.
The team studied seventy-two patients treated for a median of fourteen years. Blood counts and ninety-two inflammation proteins were measured. Disease activity was scored on a standard index. Patients were split at a twenty-gram lifetime dose. In active disease, the high-dose group ran higher on twenty-three of the proteins. The finding complicates the idea that more steroid history simply means calmer inflammation.
Catalog record
| CREATOR | Anna Petrackova, Pavel Horak, Jakub Savara, Martina Skacelova, Eva Kriegova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |